Diisopropylethylamine → 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole

HRID 730720

반응식

HRID 730720 반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:4]=2[N:3]=1.Cl.[Cl:13][C:14]1[C:15]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:16][CH:17]=[CH:18][CH:19]=1.C(N(CC)C(C)C)(C)C>>[Cl:13][C:14]1[C:15]([N:20]2[CH2:21][CH2:22][N:23]([C:2]3[NH:6][C:5]4[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:4]=4[N:3]=3)[CH2:24][CH2:25]2)=[N:16][CH:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 116296552-chloro-6-methyl-1H-1,3-benzodiazoleHCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

생성물 1

HCID 578351352-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole

실험 절차

The reaction of 2-chloro-6-methyl-1H-benzoimidazole (0.202 g, 1.59 mmol, Example 14b), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.373 g, 1.22 mmol, Example 3b) and N,N-diisopropylethylamine (0.56 mL, 3.2 mmol, Aldrich) under the conditions of Example 3c afforded the title compound as a white solid. M.p. 258-259° C. MS (ESI, pos. ion) m/z: 328 (M+1).

출처 및 근거

ORD 기록
ord-2cb71b80084d4186b1692dba71bbee45
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582761B2

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