1-Methyl-1H-pyrrolo[2,3-B]pyridine-5-carbonitrile → HCID 66837868, 화합물

HRID 73117노트

반응식

HRID 73117 반응식
[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([C:11]#[N:12])[CH:10]=[C:5]2[CH:4]=[CH:3]1>N.CO.[Ni]>[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([CH2:11][NH2:12])[CH:10]=[C:5]2[CH:4]=[CH:3]1

참가 물질

4

반응물 1

HCID 497588931-Methyl-1H-pyrrolo[2,3-B]pyridine-5-carbonitrile

생성물 1

HCID 66837868HCID 66837868, 화합물수율 95.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 21705897Ammonia methanol용매

실험 절차

To a stirred solution of 1-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (210 mg, 1.3 mmol) in 10% NH3-MeOH (10 mL) was added Raney Nickel (0.5 mL, Raney (registered trademark) 2800 slurry in water), and the mixture was stirred at room temperature under hydrogen atmosphere for 4 hrs. The mixture was filtered through a pad of Celite (registered trademark), washed with MeOH, the filtrate was concentrated to give 200 mg (93% yield) of the titled compound as a white solid.

후처리

  1. filtrationThe mixture was filtered through a pad of Celite (registered trademark)
  2. washwashed with MeOH
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5d5178c71a1742998c0418d7869aba8b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829026B2

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