Diethylamine → HCID 178464221, 화합물

HRID 731474노트

반응식

HRID 731474 반응식
C1C=CC2N(O)N=NC=2C=1.[CH:11]1([N:17]([C@H:35]2[CH2:40][CH2:39][C@H:38]([CH3:41])[CH2:37][CH2:36]2)[C:18](=[O:34])[NH:19][C:20]2[S:21][C:22]([S:25]([N:28]([CH2:30][C:31](O)=[O:32])[CH3:29])(=[O:27])=[O:26])=[CH:23][N:24]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.CCN=C=NCCCN(C)C.[CH:53]([N:56](C(C)C)[CH2:57][CH3:58])(C)[CH3:54].C(NCC)C>CN(C=O)C>[CH:11]1([N:17]([C@H:35]2[CH2:36][CH2:37][C@H:38]([CH3:41])[CH2:39][CH2:40]2)[C:18](=[O:34])[NH:19][C:20]2[S:21][C:22]([S:25]([N:28]([CH3:29])[CH2:30][C:31]([N:56]([CH2:57][CH3:58])[CH2:53][CH3:54])=[O:32])(=[O:27])=[O:26])=[CH:23][N:24]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

7

반응물 5

HCID 8021DiethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 178484758HCID 178484758, 화합물

생성물 1

HCID 178464221HCID 178464221, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An equimolar mixture of HOBt, ({2-[3-cyclohexyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazole-5-sulfonyl}-methyl-amino)-acetic acid was added EDAC (1.5 eq) and diisopropylethyl amine (1.2 eq) and dry DMF (10 mL/mmol). The solution was stirred 30 min at rt and then diethyl amine (1.5 eq) was added and stirring was continued over night.

후처리

  1. stirringstirring
  2. waitwas continued over night

출처 및 근거

ORD 기록
ord-50b346dae7e043ebafdc5a962b2111f4
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582769B2

반응 노트

불러오는 중…