Water → 2-[[2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	2-Amino-2-methylpropane-1,1-diol	HCID 5244174	—
반응물	7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine	HCID 11221650	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	2-[[2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol	HCID 22649035	42%

반응 조건

온도	110 °C

반응 단계

The product from step (d) (1.5 g) was suspended in NMP (10 ml), then Hunigs base (1.5 ml) and 2-Amino-2-methylpropanediol (1.37 g) added. Reaction mixture heated to 110° C. under N2 for 4 hrs. A further aliquot of 2-Amino-2-methylpropanediol (0.685 g) was added and mixture heated at 110° C. for 5 hrs. Mixture poured in to water (400 ml) and solid was collected by filtration. Purified by column chromatography (EtOAc: Methanol (95:5)) to give 0.756 g of product. 42% yield.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07585867B2
출처 데이터셋	uspto-grants-2009_09
ORD ID	ord-5e06f1e3b0214ea78b27093ecf157865
출처 메모	uspto-grants-2009_09