反应详情

温度

110 °C

The product from step (d) (1.5 g) was suspended in NMP (10 ml), then Hunigs base (1.5 ml) and 2-Amino-2-methylpropanediol (1.37 g) added. Reaction mixture heated to 110° C. under N2 for 4 hrs. A further aliquot of 2-Amino-2-methylpropanediol (0.685 g) was added and mixture heated at 110° C. for 5 hrs. Mixture poured in to water (400 ml) and solid was collected by filtration. Purified by column chromatography (EtOAc: Methanol (95:5)) to give 0.756 g of product. 42% yield.

1. customReaction mixture
2. temperaturemixture heated at 110° C. for 5 hrs
3. filtrationwas collected by filtration
4. customPurified by column chromatography (EtOAc: Methanol (95:5))