Hydrochloric Acid → HCID 58080194, 화합물
반응식
[NH2:1][C@@H:2]([CH2:9][S:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][C:4]([N:6]([CH3:8])[CH3:7])=O.CO.Cl>C1COCC1>[NH2:1][C@@H:2]([CH2:9][S:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:3][CH2:4][N:6]([CH3:8])[CH3:7]참가 물질
5
실험 절차
A solution of EXAMPLE 1L (8.68 g, 36.5 mmol) in THF (200 mL) was treated with BH3-dimethylsulfide (18.2 mL, 182.5 mmol) at room temperature, stirred overnight, treated slowly with methanol (20 mL), followed by 2N HCl (50 mL), stirred overnight, and concentrated. The resulting residue was purified by silica gel chromatography eluting with 5% 7N NH3/CH3OH in dichloromethane to give the desired product (4.50 g, 55%). MS (CI) m/e 224 (M+H)+.
후처리
- stirringstirred overnight
- concentrationconcentrated
- customThe resulting residue was purified by silica gel chromatography
- washeluting with 5% 7N NH3/CH3OH in dichloromethane
출처 및 근거
- ORD 기록
- ord-991bf97da32b4c229899f08f97064be6
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07585858B2
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