Lithium Hexamethyldisilazide → 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide

HRID 731545

반응식

HRID 731545 반응식
[C:1]1([C:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].C[Si]([N-:35][Si](C)(C)C)(C)C>O1CCCC1>[C:24]1([C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:8][CH2:9][N:10]2[CH2:11][CH2:12][N:13]([C:16]3[CH:17]=[CH:18][C:19]([C:20](=[NH:35])[NH2:21])=[CH:22][CH:23]=3)[CH2:14][CH2:15]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

4

반응물 2

HCID 2733832Lithium HexamethyldisilazideHCID 591866114-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzonitrile

생성물 1

HCID 591866074-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide수율 83.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of EXAMPLE 12A (0.515 g, 1.36 mmol) in dry tetrahydrofuran (6 mL) was treated dropwise with LiHMDS (1M, 6.8 mL, 6.8 mmol), stirred for 16 hours, quenched with 1N HCl (8 mL), and filtered. The filter cake was collected to provide the desired product (0.45 g, 71%) that was used without further purification. MS (CI) m/e 397 (M+H)+.

후처리

  1. customquenched with 1N HCl (8 mL)
  2. filtrationfiltered
  3. customThe filter cake was collected

출처 및 근거

ORD 기록
ord-f615de3334bf4e5d8dc073a1350c2764
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585858B2

연결된 노트

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