Ammonium Chloride → (2,3-Dichloro-6-nitrophenyl)methanol

HRID 731677

반응식

HRID 731677 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+].[Cl-].[NH4+]>CO>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[CH2:4][OH:5]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 112182712,3-Dichloro-6-nitrobenzaldehyde

생성물 1

HCID 11160370(2,3-Dichloro-6-nitrophenyl)methanol수율 91.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

196MBT36 (100 mg, 0.455 mmol) was dissolved in methanol (2 mL). Sodium borohydride (17 mg, 0.455 mmol) was added and the mixture was stirred for 30 minutes at room temperature. Saturated aqueous ammonium chloride (1 mL) was added and extracted with dichloromethane (2×10 mL). The combined organic phases were dried over Na2SO4, filtered and evaporated to give 2,3-dichloro-6-nitrobenzyl alcohol (196MBT46-A, 92 mg, 91%) as a yellow solid.

후처리

  1. extractionextracted with dichloromethane (2×10 mL)
  2. dry with materialThe combined organic phases were dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-40beb7fda9d44a468b721181526bd306
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585877B2

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