Hydrazine hydrate (1:1) → 3-Cyanobenzohydrazide

HRID 732027

반응식

HRID 732027 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[N:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[C:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([NH:14][NH2:15])=[O:2])#[N:11]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 83554Benzoic acid, 3-cyano-, methyl ester

생성물 1

HCID 219426583-Cyanobenzohydrazide수율 52.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-cyano-benzoic acid methyl ester (2 g, 12 mmol) and hydrazine monohydrate (0.60 mL, 12 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and then the residue was triturated with diethyl ether to afford 3-cyano-benzoic acid hydrazide (1.02 g, 51%, pink solid). 1H NMR (DMSO) □ (ppm): 10.31 (s, 1H), 8.21 (m, 1H), 8.11 (m, 1H), 7.99 (m, 1H), 7.70 (m, 1H), 4.50 (s, 1H).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-9de038fd9408409d98c15b6450e01aa9
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585881B2

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