Sodium Hydroxide → 3-(3-Cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid

HRID 732102노트

반응식

HRID 732102 반응식
C([O:3][C:4](=[O:22])[CH:5]([CH3:21])[CH2:6][C:7]1[N:8]([CH:18]2[CH2:20][CH2:19]2)[C:9]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:10][CH:11]=1)C.[OH-].[Na+]>CO>[CH:18]1([N:8]2[C:7]([CH2:6][CH:5]([CH3:21])[C:4]([OH:22])=[O:3])=[CH:11][N:10]=[C:9]2[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH2:19][CH2:20]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 578379853-(3-cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid ethyl ester

생성물 1

HCID 578379903-(3-Cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid수율 76.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-(3-cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid ethyl ester (1.02 g, 3.40 mmol) was mixed with MeOH (8 ml) and sodium hydroxide (1N in water, 5.1 ml, 5.10 mmol). This mixture was left stirring at r.t. for 5 h, followed by concentration in-vacuo. The isolated residue was treated with aq. HCl (2N, 6 ml) to isolate the title compound (702 mg, 76%). 1H-NMR (DMSO-d6): 8.63 (dd, 2H), 7.74 (dd, 2H), 6.82 (s, 1H), 3.55 (m, 1H), 3.09 (m, 1H), 2.82 (m, 2H), 1.19 (d, 3H), 1.08 (m, 2H), 0.56 (m, 2H).

후처리

  1. waitThis mixture was left
  2. concentrationfollowed by concentration in-vacuo
  3. additionThe isolated residue was treated with aq. HCl (2N, 6 ml)

출처 및 근거

ORD 기록
ord-e2effea10bbe433ea6023d818120c84e
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585881B2

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