Propylamine → HCID 23143269, 화합물

HRID 732179노트

반응식

HRID 732179 반응식
Cl[C:2]1[O:3][C:4]([CH3:13])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH2:14]([NH2:17])[CH2:15][CH3:16]>C(O)C>[CH3:13][C:4]1[O:3][C:2]([NH:17][CH2:14][CH2:15][CH3:16])=[N:6][C:5]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 23143330HCID 23143330, 화합물

생성물 1

HCID 23143269HCID 23143269, 화합물수율 52%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
110 °C

실험 절차

To a solution of 2-chloro-5-methyl-4-phenyl-1,3-oxazole (1.46 g, 7.56 mmol) in ethanol (15 mL) was added propylamine (5 mL), and the mixture was stirred in a sealed tube at 110° C. for 8 hr. The reaction mixture was concentrated and water was added. The mixture was extracted with ethyl acetate, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=2:1) to give the title compound (850 mg, yield 52%) as a yellow powder.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added
  3. extractionThe mixture was extracted with ethyl acetate
  4. washwashed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-f62c279acaac4d96a49ec6c22f8f7fd4
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585880B2

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