HCID 68816243, 화합물 → HCID 68816405, 화합물

HRID 732559노트

반응식

HRID 732559 반응식
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15]([C:17](=[O:21])[C:18]([CH3:20])=[CH2:19])[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1>C(OCC)(=O)C.[Ni]>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15]([CH:17]([OH:21])[CH:18]([CH3:19])[CH3:20])[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1

참가 물질

4

반응물 1

HCID 68816243HCID 68816243, 화합물

생성물 1

HCID 68816405HCID 68816405, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8857Ethyl Acetate용매

실험 절차

Dissolve N-methyl-5-(2-methylacryloyl)-N-propyl-isophthalamic acid methyl ester (80 mg, 0.26 mmol) in ethyl acetate (25 mL) under nitrogen. Add Raney® nickel (100 mg) and hydrogenate the reaction for 2 h at room temperature under an atmosphere of hydrogen gas (40 psi). Filter the reaction and concentrate to give the crude title product.

후처리

  1. customthe reaction for 2 h at room temperature under an atmosphere of hydrogen gas (40 psi)
  2. filtrationFilter
  3. customthe reaction
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-0439aca99a4e4c31ad4930a3dea38031
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585885B2

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