Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyldimethylsilyl chloride → 1-Benzyl-3-t-butyldimethylsilyloxymethylpyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-Benzyl-3-t-butyldimethylsilyloxymethylpyrrolidine | HCID 19914927 | — |
반응 단계
Diisopropylethylamine and tert-butyldimethyl-chlorosilane were added in that order to a chloroform solution of (1-benzylpyrrolidin-3-yl)methanol and stirred at room temperature for 5Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl]pyrrolidine. EP: 306.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585886B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-22633246d1ab409e8e61f01d745b9caa |
| 출처 메모 | uspto-grants-2009_09 |