Dimethyl Sulfoxide → 5-Oxo-1-phenylpyrrolidine-3-carboaldehyde

HRID 732668노트

반응식

HRID 732668 반응식
C(Cl)(=O)C(Cl)=O.ClCCl.CS(C)=O.[OH:14][CH2:15][CH:16]1[CH2:20][N:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:18](=[O:27])[CH2:17]1>C(N(CC)CC)C>[O:27]=[C:18]1[N:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:20][CH:16]([CH:15]=[O:14])[CH2:17]1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 6344Dichloromethane2회HCID 65578Oxalyl chlorideHCID 100127634-(Hydroxymethyl)-1-phenylpyrrolidin-2-one

생성물 1

HCID 866285405-Oxo-1-phenylpyrrolidine-3-carboaldehyde

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Oxalyl chloride was added to a dichloromethane solution of DMSO at −78° C. and stirred for 20 minutes. Successively, this was mixed with a dichloromethane solution of 4-(hydroxymethyl)-1-phenylpyrrolidin-2-one and then with triethylamine 15 minutes thereafter, and stirred for 30 minutes. Thereafter, work-up and purification were carried out to obtain 5-oxo-1-phenylpyrrolidine-3-carboaldehyde. EN: 188.

후처리

  1. customThereafter, work-up and purification

출처 및 근거

ORD 기록
ord-35afcc8ddec64e3fb0987350007e77e2
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585886B2

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