Hydrochloric Acid → 2-[4-(1-amino-1-methylethyl)phenyl]-3-(2-thienyl)-1,6-naphthyridin-5(6H)-one

HRID 732875노트

반응식

HRID 732875 반응식
C[O:2][C:3]1[N:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([C:23]1[S:24][CH:25]=[CH:26][CH:27]=1)[C:7]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([NH2:22])([CH3:21])[CH3:20])=[CH:15][CH:14]=1)=[N:8]2.Cl>C1COCC1>[NH2:22][C:19]([C:16]1[CH:15]=[CH:14][C:13]([C:7]2[C:6]([C:23]3[S:24][CH:25]=[CH:26][CH:27]=3)=[CH:5][C:4]3[C:3](=[O:2])[NH:12][CH:11]=[CH:10][C:9]=3[N:8]=2)=[CH:18][CH:17]=1)([CH3:21])[CH3:20]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 690592742-{4-[5-Methoxy-3-(2-thienyl)-1,6-naphthyridin-2-yl]phenyl}propan-2-amine

생성물 1

HCID 118549652-[4-(1-amino-1-methylethyl)phenyl]-3-(2-thienyl)-1,6-naphthyridin-5(6H)-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-{4-[5-methoxy-3-(2-thienyl)-1,6-naphthyridin-2-yl]phenyl}propan-2-amine (2-6, 66 mg, 0.176 mmol) in THF (10 mL) was added concentrated HCl (1 mL) and stirred for 5 h at rt. The volatiles were evaporated in vacuo and the residue was partitioned between saturated sodium bicarbonate solution and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to give the title compound as an off-white solid. LRMS m/z (M+1) Calcd: 362.1,. Found 362.2.

후처리

  1. customThe volatiles were evaporated in vacuo
  2. customthe residue was partitioned between saturated sodium bicarbonate solution and ethyl acetate
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4a54003a015341c3b62e272e9fcddc62
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589068B2

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