Aniline → N-(3,4-Dichloro-phenyl)-2-phenylamino-acetamide
반응식
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1)=[O:4].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(C(C)C)C(C)C)C>C1COCC1>[Cl:13][C:8]1[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:11]=[CH:10][C:9]=1[Cl:12]참가 물질
5
실험 절차
To 2-bromo-N-(3,4-dichloro-phenyl)-acetamide (2 g) in THF (80 mL) was added aniline (41 mg) and N-ethyldiisopropylamine and the reaction mixture was stirred over night at reflux. The precipitated salt was then filtered off and the filtrate was then concentrated in vacuo. The residue was then purified by column chromatography to give the title compound as a light brown solid (1.3 g, mp=110-112° C.).
후처리
- temperatureat reflux
- filtrationThe precipitated salt was then filtered off
- concentrationthe filtrate was then concentrated in vacuo
- customThe residue was then purified by column chromatography
출처 및 근거
- ORD 기록
- ord-4fb9c061612d47e7be6cf8c1001922d4
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07589089B2
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