Sodium Hydroxide → HCID 9813851, 화합물

HRID 732983노트

반응식

HRID 732983 반응식
[NH2:1][C:2]1[N:3]=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([O:14]CC)=[O:13])[C:6]=2[N:7]=1.[OH-].[Na+].B(Br)(Br)Br>CO>[NH2:1][C:2]1[N:3]=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[N:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 25134Boron tribromideHCID 9921985Ethyl 5-Amino-7-(2-Furyl)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-Ylacetate

생성물 1

HCID 9813851HCID 9813851, 화합물수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of ethyl 5-amino-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-ylacetate (547 mg, 1.89 mmol) in MeOH (5 mL) was treated with aqueous NaOH (2 mL, 2-M, 4 mmol), refluxed for 10 min, cooled, acidified with aqueous HCl (1-M), filtered and dried to give the title compound (417 mg, 85%) as a white solid.

후처리

  1. temperaturerefluxed for 10 min
  2. temperaturecooled
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-ae682b777df547e3beba023d3e9e2b89
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589097B2

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