Water → HCID 21874759, 화합물

HRID 733014노트

반응식

HRID 733014 반응식
[NH2:1][C:2]1[N:3]=[C:4]([C:25]2[O:26][CH:27]=[CH:28][CH:29]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19](=O)[O:20]CC)=[C:14]([CH3:24])[CH:13]=3)[C:6]=2[N:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+].O>C1COCC1>[NH2:1][C:2]1[N:3]=[C:4]([C:25]2[O:26][CH:27]=[CH:28][CH:29]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][CH:19]=[O:20])=[C:14]([CH3:24])[CH:13]=3)[C:6]=2[N:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 10135175HCID 10135175, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 21874759HCID 21874759, 화합물수율 7.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of ethyl 4-((5-amino-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-3-yl)methyl)-2-methylphenylcarbamate (318 mg, 0.81 mmol) and LiAlH4 (62 mg, 1.62 mmol) in dry THF (30 mL) was refluxed overnight, cooled to room temperature, treated with 13% aqueous NaOH solution (0.1 mL) then water (0.3 mL), stirred for 30 min, filtered through Celite and concentrated in vacuo. The resulting solid was triturated with THF and filtered to give the title compound (20 mg, 7%) as a yellow solid.

후처리

  1. temperaturewas refluxed overnight
  2. filtrationfiltered through Celite
  3. concentrationconcentrated in vacuo
  4. customThe resulting solid was triturated with THF
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-2fe827aec1e74c818e3694ec75c1eb0c
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589097B2

반응 노트

불러오는 중…