Iodine → 1-Bromo-3-cyclopropylbenzene

HRID 733193

반응식

HRID 733193 반응식
II.I[CH2:4]I.[Br:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.[Cu]>[Br:6][C:7]1[CH:8]=[C:9]([CH:10]2[CH2:4][CH2:11]2)[CH:12]=[CH:13][CH:14]=1

참가 물질

6

반응물 3

HCID 807IodineHCID 6346DiiodomethaneHCID 748703-Bromostyrene

생성물 1

HCID 32826721-Bromo-3-cyclopropylbenzene수율 10.6%

시약·촉매·용매 2

HCID 23978Copper촉매HCID 1140Toluene용매

실험 절차

Iodine (0.335 g, 1.32 mmol), diiodomethane (4.3 mL, 53.0 mmol) and 3-bromostyrene (5 g, 26.4 mmol) were added successively to a suspension of copper (7.5 g, 118.8 mmol) in toluene (50 mL). The mixture was refluxed for 140 h, then filtered and concentrated in vacuo. The residue was distilled under reduced pressure to afford 3-bromo-1-cyclopropylbenzene (0.55 g, 10%) as a colorless oil.

후처리

  1. temperatureThe mixture was refluxed for 140 h
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo
  4. distillationThe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-92a3c950b0de4d5d9a1452cdff580344
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589095B2

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