Formamide → 4-Chloro-phthalimide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.O.C([NH2:16])=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:8])[NH:16][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1

참가 물질

반응물 3

HCID 713Formamide

HCID 962Water

HCID 670444-Chlorophthalic anhydride

생성물 1

HCID 2312394-Chloro-phthalimide수율 104.6%

반응 조건

온도: 20 °C

실험 절차

A solution of 10.0 g of 4-chlorophthalic anhydride in 24.6 g of formamide is heated at a temperature in the region of 120° C. with stirring for 3 hours and is then cooled to a temperature in the region of 20° C. and poured into 100 cm3 of water. After stirring for 30 minutes, the mixture is filtered and the precipitate is then dried under vacuum at a temperature in the region of 60° C. 10.4 g of 4-chlorophthalimide are thus obtained in the form of a solid melting at 171° C. Rf=0.07 (thin layer chromatography on silica gel, eluent: dichloromethane).

후처리

stirringAfter stirring for 30 minutes
filtrationthe mixture is filtered
customthe precipitate is then dried under vacuum at a temperature in the region of 60° C

출처 및 근거

ORD 기록: ord-e76a3d7582734eb9a8ba17749f6bed4d
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07589117B2

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