Water → 1-Methoxy-2-methyl-4-nitrobenzene

HRID 73341

반응식

HRID 73341 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[C:12](=O)([O-])[O-].[K+].[K+].IC.O>CN(C)C=O>[CH3:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 74422-Methyl-4-nitrophenolHCID 11430Potassium Carbonate

생성물 1

HCID 6435201-Methoxy-2-methyl-4-nitrobenzene수율 87%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1-hydroxy-2-methyl-4-nitrobenzene (1.0 g) in N,N-dimethylformamide (10 mL) were added potassium carbonate (1.8 g) and iodomethane (1.3 g) at room temperature and this mixture was stirred at the same temperature for 24 hours. This reaction mixture was poured into water and this resulting mixture was extracted with ethyl acetate. This organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.95 g).

후처리

  1. extractionthis resulting mixture was extracted with ethyl acetate
  2. washThis organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-e4981e2027d4417e8bedfd6f042872dc
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829040B2

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