Methyl iodide → HCID 57840842, 화합물

HRID 733685노트

반응식

HRID 733685 반응식
[Br:1][C:2]1[C:7]2[CH:8]=[CH:9][NH:10][C:6]=2[C:5]([Br:11])=[CH:4][N:3]=1.IC.[C:14](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[C:7]2[CH:8]=[CH:9][N:10]([CH3:14])[C:6]=2[C:5]([Br:11])=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 247294414,7-Dibromo-1H-pyrrolo[3,2-c]pyridine

생성물 1

HCID 57840842HCID 57840842, 화합물수율 69.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4,7-dibromo-1H-pyrrolo[3,2-c]pyridine (1.35 g), iodomethane (609 ul) and anhydrous potassium carbonate (1.35 g) in dry acetone (90 ml) was refluxed overnight. The mixture was evaporated and the residue added to ethyl acetate (60 ml) and water (60 ml). The organic layer was washed with water then brine, dried (MgSO4) and evaporated. Purification of the residue by chromatography on silica gel, eluting with dichloromethane, gave the title compound (0.99 g)

후처리

  1. temperaturewas refluxed overnight
  2. customThe mixture was evaporated
  3. additionthe residue added to ethyl acetate (60 ml) and water (60 ml)
  4. washThe organic layer was washed with water
  5. dry with materialbrine, dried (MgSO4)
  6. customevaporated
  7. customPurification of the residue by chromatography on silica gel
  8. washeluting with dichloromethane

출처 및 근거

ORD 기록
ord-3e339e066128492897a344712ee1f386
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589206B2

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