Sodium Hydroxide → 4-Chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid

HRID 733723노트

반응식

HRID 733723 반응식
C[O:2][C:3]([C:5]1[C:6]2[N:14]([CH3:15])[CH:13]=[CH:12][C:7]=2[C:8]([Cl:11])=[N:9][CH:10]=1)=[O:4].[OH-].[Na+]>CO>[Cl:11][C:8]1[C:7]2[CH:12]=[CH:13][N:14]([CH3:15])[C:6]=2[C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 44475508Methyl 4-chloro-1-methyl-1H-pyrrolo(3,2-c)pyridine-7-carboxylate

생성물 1

HCID 578409034-Chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid수율 98.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.5 g), in methanol (20 ml) was added aqueous 2M sodium hydroxide solution (2 ml) and the mixture was heated to reflux for 4 hours. The methanol was evaporated and the residue was dissolved in water (50 ml) and acidified to pH 1 using aqueous 2M hydrochloric acid. Solid sodium chloride was added to saturated the aqueous phase, the solution was extracted with tetrahydrofuran (2×50 ml). The tetrahydrofuran layers were combined and evaporated to afford the title compound (460 mg).

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customThe methanol was evaporated
  4. dissolutionthe residue was dissolved in water (50 ml)
  5. additionSolid sodium chloride was added to saturated the aqueous phase
  6. extractionthe solution was extracted with tetrahydrofuran (2×50 ml)
  7. customevaporated

출처 및 근거

ORD 기록
ord-fe0c20e70d014f5980cabd7cc0e0d41e
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589206B2

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