Water → 1-(2-Bromo-3,5,6-trimethylphenyl)ethanone
반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[CH3:10].[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-].O>ClCCl>[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH3:9])=[C:6]([CH3:8])[C:7]=1[C:11](=[O:13])[CH3:12]참가 물질
6
실험 절차
To a mixture of 1-bromo-2,4,5-trimethylbenzene (5.0 g, 25.0 mmol) and acetyl chloride (2.45 ml, 34.5 mmol) in dichloromethane (50 ml) was added aluminium chloride (4.42 g, 33.1 mmol) in dichloromethane (50 ml) and the reaction mixture was stirred at room temperature for 18 h. The mixture was poured into water and the two layers were separated. The organic phase was washed with saturated aqueous sodium hydrogen carbonate solution, dried (MgSO4) and filtered through silica. The filtrate was concentrated in vacuo to give the title compound (5.50 g).
후처리
- customthe two layers were separated
- washThe organic phase was washed with saturated aqueous sodium hydrogen carbonate solution
- dry with materialdried (MgSO4)
- filtrationfiltered through silica
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-de994c566245469aa291f3d09cf5d79b
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07592362B2
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