Methanol → Methyl 4-chloro-3-sulfamoylbenzoate
반응식
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:15]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([O:10][CH3:15])=[O:9])(=[O:4])=[O:3]참가 물질
5
실험 절차
3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.
후처리
- washwashed with water, brine
- dry with materialdried (Na2SO4)
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-2ba078ff6fe9468996bc53adcbb229cd
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07592357B2
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