Methanol → Methyl 4-chloro-3-sulfamoylbenzoate

HRID 734733

반응식

HRID 734733 반응식
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:15]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([O:10][CH3:15])=[O:9])(=[O:4])=[O:3]

참가 물질

5

반응물 2

HCID 887MethanolHCID 145684-Chloro-3-sulfamoylbenzoic acid

생성물 1

HCID 4277179Methyl 4-chloro-3-sulfamoylbenzoate수율 95%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 8857Ethyl Acetate용매

실험 절차

3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.

후처리

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-2ba078ff6fe9468996bc53adcbb229cd
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592357B2

연결된 노트

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