Water → 5-Bromo-2-(2-pyrrolidin-1-ylethoxy)benzylamine

HRID 734849노트

반응식

HRID 734849 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[N:20]([CH2:23][C:24]1[CH:37]=[C:36]([Br:38])[CH:35]=[CH:34][C:25]=1[O:26][CH2:27][CH2:28][N:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1)=[N+]=[N-].O>C1COCC1>[Br:38][C:36]1[CH:35]=[CH:34][C:25]([O:26][CH2:27][CH2:28][N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[C:24]([CH:37]=1)[CH2:23][NH2:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 860769251-[2-(2-Azidomethyl-4-bromophenoxy)ethyl]pyrrolidine

생성물 1

HCID 608783045-Bromo-2-(2-pyrrolidin-1-ylethoxy)benzylamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.66 g (2.50 mmol) of triphenylphosphine was added to a solution of 0.40 g (1.23 mmol) 1-[2-(2-azidomethyl-4-bromophenoxy)ethyl]pyrrolidine in 5 mL of THF and the mixture was stirred for 30 minutes at RT. Water was added and the aqueous phase was exhaustively extracted with DCM. The combined organic extracts were dried over magnesium sulfate and evaporated down in vacuo. Yield: 0.185 g (50% of theoretical); C13H19BrN2O (M=299.207); calc.: molpeak (M+H)+: 299/301 (Br); found: molpeak (M+H)+: 299/301 (Br); HPLC-MS: 1.38 minutes (method A).

후처리

  1. extractionthe aqueous phase was exhaustively extracted with DCM
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. customevaporated down in vacuo
  4. custom1.38 minutes (method A)

출처 및 근거

ORD 기록
ord-7cb3bb0020624d43912b34a8c10b5490
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592358B2

반응 노트

불러오는 중…