홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hexane → 3-(4-bromo-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione

HRID 735246
노트
인쇄 미리보기

반응식

HRID 735246 반응식
CO[C:3](=[O:24])[C:4]1[C:9]([Cl:10])=[CH:8][C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][C:13](=[O:23])[CH:14]([C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)[CH3:15].[H-].[Na+].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.CCCCCC>CCOC(C)=O>[Br:22][C:19]1[CH:20]=[CH:21][C:16]([C:14]2([CH3:15])[C:3](=[O:24])[C:4]3[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][C:9]=3[Cl:10])[NH:12][C:13]2=[O:23])=[CH:17][CH:18]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 8058HexaneHCID 24758Sodium hydrideHCID 2733832Lithium hexamethyldisilazaneHCID 688165642-[2-(4-Bromo-phenyl)-propionylamino]-4,6-dichlorobenzoic acid methyl ester

생성물 1

HCID 115603623-(4-bromo-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione수율 18%

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매

실험 절차

The objective compound was prepared by the same procedure for the example 1, using a 2-[2-(4-bromo-phenyl)-propionyl amino]-4,6-dichloro-benzoic acid methyl ester (400 mg, 0.93 mmol) and NaH (78 mg, 1.95 mmol) as a base instead of LiHMDS. After normal workup, the objective compound (60 mg, 18%) was obtained as white solid by a flash column chromatography (n-hexane:EtOAc=5:1): 1H NMR (200 MHz, CDCl3+CD3OD) δ 1.69 (s, 3H, CH3), 6.91-7.48 (m , 6H, ArH); m.p. 237-238° C.; MS(EI) m/e 397 [M+].

후처리

  1. customThe objective compound was prepared by the same procedure for the example 1

출처 및 근거

ORD 기록
ord-8ee734c2109340dda1f22ffd2c677d28
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592457B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트