홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → HCID 11641840, 화합물

HRID 735410
노트
인쇄 미리보기

반응식

HRID 735410 반응식
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][C:20](Br)=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:24]([F:27])([F:26])[F:25])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br-].[CH3:29][O:30][C:31]([C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH2:36][Zn+])=[O:32].Cl.ClCCl>C1COCC1>[CH3:29][O:30][C:31](=[O:32])[C:33]1[CH:40]=[CH:39][CH:38]=[C:35]([CH2:36][C:20]2[CH:21]=[CH:22][C:17]([C:16]3[N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[N:9]=[C:10]4[C:15]=3[CH:14]=[CH:13][CH:12]=[C:11]4[C:24]([F:26])([F:27])[F:25])=[CH:18][CH:19]=2)[CH:34]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 670210292-Benzyl-3-(4-bromo-phenyl)-7-trifluoromethyl-2H-indazoleHCID 178497761HCID 178497761, 화합물

생성물 1

HCID 11641840HCID 11641840, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매
2회

실험 절차

2-Benzyl-3-(4-bromo-phenyl)-7-trifluoromethyl-2H-indazole (43 mg, 0.1 mmol) and 4 mg of bis[triphenylphosphine]palladium(II) chloride were dissolved in THF. After 5 minutes, 0.4 ml of a 0.5M solution of 3-(methoxycarbonyl)-benzylzinc bromide in THF (0.2 mmol) were added and the reaction mixture was stirred at room temperature overnight. 1M HCl-solution and dichloromethane were added, and the phases were separated. The resulting product was obtained after flash chromatographic purification using n-heptane/ethyl acetate, 90:10, as eluent. Yield: 47 mg.

후처리

  1. customthe phases were separated
  2. customThe resulting product was obtained
  3. customafter flash chromatographic purification

출처 및 근거

ORD 기록
ord-f2a45e7c95624f07954c6e8ceb25976c
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592363B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트