Sodium Hydroxide → 5-(4-Boronophenyl)pentanoic acid

HRID 735499노트

반응식

HRID 735499 반응식
B(C1C=CC(CCCC(O)=O)=CC=1)(O)O.CC1(C)C[O:21][B:20]([C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:25][CH:24]=2)[O:19]C1.[OH-].[Na+]>>[B:20]([C:23]1[CH:24]=[CH:25][C:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:27][CH:28]=1)([OH:21])[OH:19]

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 578425984-(4-Boronophenyl)butanoic acidHCID 578428175-(4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)pentanoic acid

생성물 1

HCID 578427605-(4-Boronophenyl)pentanoic acid수율 76.1%

실험 절차

Using a procedure analogous to that used to prepare 2B, 5A (429 mg, 1.48 mmol) was reacted with NaOH to afford 5B (250 mg, 76%) as an off-white solid.

출처 및 근거

ORD 기록
ord-48ef29e38e2243e59200679cc9e18051
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592331B2

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