홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Phosphorus oxychloride → Benzyl 5-(2-(4-bromo-2,6-dimethylphenoxy)acetamido)-2-(ethylsulfonyl)benzylcarbamate

HRID 735708
노트
인쇄 미리보기

반응식

HRID 735708 반응식
[Br:1][C:2]1[CH:12]=[C:11]([CH3:13])[C:5]([O:6][CH2:7][C:8]([OH:10])=O)=[C:4]([CH3:14])[CH:3]=1.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([S:34]([CH2:37][CH3:38])(=[O:36])=[O:35])=[C:20]([CH:33]=1)[CH2:21][NH:22][C:23](=[O:32])[O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.O=P(Cl)(Cl)Cl>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]([O:6][CH2:7][C:8]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([S:34]([CH2:37][CH3:38])(=[O:36])=[O:35])=[C:20]([CH:33]=2)[CH2:21][NH:22][C:23](=[O:32])[O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:10])=[C:11]([CH3:13])[CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 24813Phosphorus oxychlorideHCID 7248362-(4-Bromo-2,6-dimethylphenoxy)acetic acidHCID 57842737HCID 57842737, 화합물

생성물 1

HCID 57842885Benzyl 5-(2-(4-bromo-2,6-dimethylphenoxy)acetamido)-2-(ethylsulfonyl)benzylcarbamate수율 98%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 79A (100 mg, 0.386 mmol) and 28A (148 mg, 0.386 mmol) in 2 mL pyridine at −15° C., was added POCl3 (0.040 mL, 0.425 mmol), dropwise. The mixture was stirred at this temperature for 20 min, then was quenched with water. The mixture was diluted with EtOAc, washed with water (2×), 1N HCl, water, sat. NaHCO3 and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography to afford 222 mg (98%) of 79B as a colorless oil. MS (ESI) m/z 589.2 (M+H)+.

후처리

  1. customwas quenched with water
  2. additionThe mixture was diluted with EtOAc
  3. washwashed with water (2×), 1N HCl, water, sat. NaHCO3 and brine
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated
  6. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-0b7170529d054cb483a301c0922813a2
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592331B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트