Sodium Hydroxide → 4-Cyano-3-methoxybenzoic acid

HRID 735741노트

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HRID 735741 반응식
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])#[N:2].[OH-].[Na+]>CO>[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])#[N:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22464400Methyl 4-cyano-3-methoxybenzoate

생성물 1

HCID 187797844-Cyano-3-methoxybenzoic acid수율 106.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution (37 ml) of methyl 4-cyano-3-methoxybenzoate (700 mg, 3.66 mmol) in methanol was added 1M aqueous sodium hydroxide solution (37 ml), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, the residue was dissolved in water, and the mixture was washed with diethyl ether. The aqueous layer was neutralized with 1M hydrochloric acid and extracted with dichloromethane. The extract was dried over anhydrous MgSO4 and concentrated under reduced pressure to give the title compound (690 mg, ca. 100%) as a white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in water
  3. washthe mixture was washed with diethyl ether
  4. extractionextracted with dichloromethane
  5. dry with materialThe extract was dried over anhydrous MgSO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-841afae2839641e0a7979e26a81bbf6a
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592453B2

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