Sodium Azide → Methyl 4-(azidomethyl)-1-naphthoate
반응식
Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1.[N-:17]=[N+:18]=[N-:19].[Na+]>CS(C)=O.O>[N:17]([CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1)=[N+:18]=[N-:19]참가 물질
5
실험 절차
To a solution of methyl 4-(bromomethyl)-1-naphthoate (30 g, 0.107 mol) in anhydrous DMSO (300 mL) was added NaN3 portion wise (14 g, 0.215 mol) at 0° C. and stirred at rt for 16 h. Then the reaction mixture was diluted with water (500 mL), extracted with EtOAc (2×250 mL), washed with water, brine and dried over MgSO4. The solvent was removed under vacuum to give methyl 4-(azidomethyl)-1-naphthoate (20 g, 77%).
후처리
- extractionextracted with EtOAc (2×250 mL)
- washwashed with water, brine
- dry with materialdried over MgSO4
- customThe solvent was removed under vacuum
출처 및 근거
- ORD 기록
- ord-1603d0d10eef4ff58108e96f77f08116
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07592477B2
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