Ticlatone → 6-Chloro-3-oxo-3H-benzo[d]isothiazole-2-carboxylic acid isopropylamide

HRID 736631노트

반응식

[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[NH:7][S:8][C:4]=2[CH:3]=1.[CH:12]([N:15]=[C:16]=[O:17])([CH3:14])[CH3:13]>>[CH:12]([NH:15][C:16]([N:7]1[C:6](=[O:9])[C:5]2[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][C:4]=2[S:8]1)=[O:17])([CH3:14])[CH3:13]

참가 물질

반응물 2

HCID 6258Ticlatone

HCID 61277Isopropyl isocyanate

생성물 1

HCID 112194596-Chloro-3-oxo-3H-benzo[d]isothiazole-2-carboxylic acid isopropylamide

실험 절차

Following the synthetic procedure of 6a as described in Example 1, compound 6v (98% yield) was synthesized from 6-chloro-benzo[d]isothiazol-3-one and iso-propyl isocyanate as a white solid. IR(CHCl3) 3294, 1712, 1533 cm−1; 1H-NMR (CDCl3) δ1.29 (d, J=6.8 Hz, 6H), 4.12 (hep, J=6.8 Hz, 1H), 7.38 (d, J=8.3 Hz, 1H), 7.58 (s, 1H), 7.92 (d, J=8.2 Hz, 1H), 8.65 (br s, 1H); ESIMS m/e 271 and 273 (M++1, 35Cl and 37Cl).

출처 및 근거

ORD 기록: ord-ace2248db94244da96c54be9de63c6c0
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07595403B2

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