Acetonitrile → 1-(4-Bromo-benzyl)-3-phenyl-piperidine

HRID 737093

반응식

HRID 737093 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[C:10]1([CH:16]2[CH2:21][CH2:20][CH2:19]CN2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].[C:28](#[N:30])C>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:30]2[CH2:19][CH2:20][CH2:21][CH:16]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:28]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 1030202-Phenylpiperidine

생성물 1

HCID 578495711-(4-Bromo-benzyl)-3-phenyl-piperidine수율 54%

실험 절차

5.632 g of 4-Bromobenzyl bromide and 2.422 g of 2-Phenylpiperidine (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification was done by flash chromatography to afford product. Wt:0.908 g, 54% yield.

후처리

  1. filtrationThe solution was filtered through Celite
  2. concentrationconcentrated in vacuo
  3. customto afford a brown solid
  4. customPurification
  5. customto afford product

출처 및 근거

ORD 기록
ord-34fa2b02ab2e469ea65d7e888a05af06
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595397B2

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