Sodium Acetate → 2-Amino-4-(p-nitrophenyl)thiazole

HRID 737156노트

반응식

HRID 737156 반응식
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([O-])(=O)[CH3:6].[Na+].BrCC(O)=O.[N+:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([O-:17])=[O:16]>C(O)C>[N+:15]([C:18]1[CH:23]=[CH:22][C:21]([C:5]2[N:1]=[C:2]([NH2:4])[S:3][CH:6]=2)=[CH:20][CH:19]=1)([O-:17])=[O:16]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 86616428Nitrobenzene bromoacetate

생성물 1

HCID 164202-Amino-4-(p-nitrophenyl)thiazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.0 g (13.2 mmol) of thiourea, sodium acetate (2.2 g 26.4 mmol), and 25 mL of dry ethanol were combined in a 25 mL round bottom flask. To this suspension was added nitrobenzene bromoacetate (4.2 g, 1.72 mmol). Reaction mixture was heated under reflux overnight. This suspension was cooled to room temperature. The solid was collected by suction filtration and washed using water. The resulting solid was dried to yield 4-(4-nitro-phenyl)-thiazol-2-ylamine. MS: 222.1 (M+H+).

후처리

  1. customReaction mixture
  2. temperaturewas heated
  3. temperatureunder reflux overnight
  4. filtrationThe solid was collected by suction filtration
  5. washwashed
  6. customThe resulting solid was dried

출처 및 근거

ORD 기록
ord-8a16edf569124b38bd4b712354421325
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595398B2

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