4-(Bromoacetyl)benzonitrile → 4-(2-Amino-1,3-thiazol-4-yl)benzonitrile
반응식
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=O.[NH2:13][C:14]([NH2:16])=[S:15].CC([O-])=O.[Na+]>CCO>[NH2:16][C:14]1[S:15][CH:2]=[C:3]([C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=2)[N:13]=1참가 물질
5
실험 절차
4-(2-Bromo-acetyl)-benzonitrile (2.9 g, 12.9 mmol) was combined with 1.0 g (12.9 mmol) of thiourea. This mixture was suspended in 60 mL of EtOH. To this suspension was added NaOAc (1.4 g, 16.8 mmol). This suspension was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure to yield the desired product.
후처리
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-0915e36709dc4aa0847f2f605cd6a932
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07595398B2
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