Diisopropylethylamine → HCID 59140928, 화합물

HRID 737180노트

반응식

HRID 737180 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN([C:19]([O:23]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[N:49]1[CH:54]=[CH:53][CH:52]=[C:51]([C:55]2[N:56]=[C:57]([NH2:60])[S:58][CH:59]=2)[CH:50]=1>CN(C=O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:19](=[O:23])[NH:60][C:57]1[S:58][CH:59]=[C:55]([C:51]2[CH:50]=[N:49][CH:54]=[CH:53][CH:52]=2)[N:56]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 1548934-(3-Pyridinyl)-2-thiazolamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 10608307Phenylmethyl 1-pyrrolidinecarboxylate

생성물 1

HCID 59140928HCID 59140928, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Pyrrolidine-1-carboxylic acid benzyl ester, (224 mg, 0.9 mmol) was combined with 376 mg (1.0 mmol) of HATU. This mixture was dissolved in 15 ml of DMF. To this solution was added DIEA (1.8 mmol, 0.3 mL). This solution was stirred at room temperature for 1.5 hours. To this solution was then added 4-pyridin-3-yl-thiazol-2-ylamine (100 mg, 0.56 mg). Reaction mixture was stirred at room temperature overnight and then purified using reverse phase HPLC. MS: 409.1 (M+H+); H1 NMR (DMSO-d6): δ(ppm) (HCl salt) 12.62 (s, 1H), 9.28 (s, 1H), 8.78 (s, 1H), 8.03 (m, 2H), 7.38 (m, 3H), 7.04 (d, 2H), 5.00 (m, 2H), 4.53 (m, 1H), 3.62 (m, 2H), 2.22 (m, 1H), 1.89 (m, 4H).

후처리

  1. customReaction mixture
  2. stirringwas stirred at room temperature overnight
  3. custompurified

출처 및 근거

ORD 기록
ord-8d20a0ced70d470d87e668b52970f89b
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595398B2

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