p-Toluidine → 2-Pyridinamine, N-(4-methylphenyl)-

반응식

Cc1ccc(N)cc1.Clc1ccccn1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c(C(C)C)c1.CN(C)C(=NC(C)(C)C)N(C)C.CS(C)=O>Cc1ccc(Nc2ccccn2)cc1

참가 물질

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온도: 60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

addition기록된 절차가 없습니다

출처 및 근거

ORD 기록: ord-c1ee8c428cc544a68d9e02b04ae3e0a4
출처 데이터셋: Ahneman
DOI: 10.1126/science.aar5169

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참가 물질

반응물 2

HCID 7813p-Toluidine

HCID 79772-Chloropyridine

생성물 1

HCID 27864192-Pyridinamine, N-(4-methylphenyl)-수율 28.197%

시약·촉매·용매 3

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidine시약

HCID 178439018HCID 178439018, 화합물촉매

HCID 679Dimethyl Sulfoxide용매5회

반응 조건

온도: 60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

addition기록된 절차가 없습니다

출처 및 근거

ORD 기록: ord-c1ee8c428cc544a68d9e02b04ae3e0a4
출처 데이터셋: Ahneman
DOI: 10.1126/science.aar5169

반응 노트

불러오는 중…