p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

반응식

CCc1ccc(Br)cc1.Cc1ccc(N)cc1>CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.COc1ccc(OC)c([P](C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O>CCc1ccc(Nc2ccc(C)cc2)cc1

참가 물질

반응 조건

온도: 60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

addition기록된 절차가 없습니다

출처 및 근거

ORD 기록: ord-f8bc6a383ce04581a1e31026379bbf2d
출처 데이터셋: Ahneman
DOI: 10.1126/science.aar5169

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참가 물질

반응물 2

HCID 7813p-Toluidine

HCID 153131-Bromo-4-ethylbenzene

생성물 1

HCID 208167124-ethyl-N-(4-methylphenyl)aniline수율 79.764%

시약·촉매·용매 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramine시약

HCID 178492609HCID 178492609, 화합물촉매

HCID 679Dimethyl Sulfoxide용매5회

반응 조건

온도: 60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

addition기록된 절차가 없습니다

출처 및 근거

ORD 기록: ord-f8bc6a383ce04581a1e31026379bbf2d
출처 데이터셋: Ahneman
DOI: 10.1126/science.aar5169

반응 노트

불러오는 중…