Benzene, 1-(1,1-difluoroethoxy)-4-nitro- → Benzenamine, 4-(1,1-difluoroethoxy)-
반응식
[F:1][C:2]([F:14])([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)[CH3:3]>CCO.[Ni]>[F:1][C:2]([F:14])([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:3]참가 물질
4
실험 절차
A solution of 1-(1,1-difluoroethoxy)-4-nitrobenzene (Stage 30.4, 2.95 g, 13.94 mmol) in EtOH (100 mL) was hydrogenated (Raney Ni 1.0 g; 26.5 h at RT). The RM was filtered through Hyflo® and the solvent was evaporated off under reduced pressure to give the crude title product as a brown oil. HPLC (Condition 5) tR=4.5 min, UPLC-MS (Condition 3) tR=0.74 min, m/z=174.1 [M+H]+.
후처리
- filtrationThe RM was filtered through Hyflo®
- customthe solvent was evaporated off under reduced pressure
출처 및 근거
- ORD 기록
- ord-56d89adc9013488ca79558780be0c276
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08829195B2
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