p-Anisoyl chloride → Methyl 1-(4-methoxybenzamido)cyclohexane-1-carboxylate

HRID 73823

반응식

HRID 73823 반응식
Cl.[CH3:2][O:3][C:4]([C:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5].[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>>[CH3:2][O:3][C:4]([C:6]1([NH:12][C:19]([C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:5]

참가 물질

3

반응물 2

HCID 7477p-Anisoyl chlorideHCID 22645079Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

생성물 1

HCID 32468563Methyl 1-(4-methoxybenzamido)cyclohexane-1-carboxylate수율 71%

실험 절차

581 mg (3 mmol) of 1-aminocyclohexanecarboxylic acid methyl ester hydrochloride was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester, and 512 mg (3 mmol) of 4-methoxybenzoyl chloride was used instead of phenylacetyl chloride in the process according to Reference Example 1 to obtain 619 mg (71%) of the title compound.

출처 및 근거

ORD 기록
ord-2dde8241bbcb427b9a110f37403ccdef
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829209B2

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