2-Bromoethyl ethyl ether → 3-(2-Ethoxy-ethyl)-1H-indol-6-ylamine

HRID 73936

반응식

HRID 73936 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-])=O.Br[CH2:14][CH2:15][O:16][CH2:17][CH3:18]>CC#N>[CH2:15]([O:16][CH2:17][CH2:18][C:8]1[C:7]2[C:11](=[CH:12][C:4]([NH2:1])=[CH:5][CH:6]=2)[NH:10][CH:9]=1)[CH3:14]

참가 물질

4

반응물 2

HCID 611412-Bromoethyl ethyl etherHCID 785026-Nitro-1H-indole

생성물 1

HCID 574702023-(2-Ethoxy-ethyl)-1H-indol-6-ylamine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-(2-Ethoxy-ethyl)-1H-indol-6-ylamine (B-16) was synthesized following the general scheme above starting from 6-nitroindole and 1-bromo-2-ethoxy-ethane. Overall yield (15%). HPLC ret. time 1.56 min, 10-99% CH3CN, 5 min run; ESI-MS 205.1 m/z (MH+).

후처리

  1. customOverall yield (15%)

출처 및 근거

ORD 기록
ord-855bda40a3204eccaaf5f6d6449f9cea
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

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