2-Isopropyl-5-nitropyridine → 6-(Propan-2-yl)pyridin-3-amine

HRID 74080노트

반응식

HRID 74080 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][N:5]=1)([CH3:3])[CH3:2]>CO.[Ni]>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 450963212-Isopropyl-5-nitropyridine

생성물 1

HCID 178542886-(Propan-2-yl)pyridin-3-amine수율 52%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

2-Isopropyl-5-nitro-pyridine (1.30 g, 7.82 mmol) was dissolved in methyl alcohol (20 mL), and Raney Ni (0.25 g) was added. The mixture was stirred under H2 (1 atm) at room temperature for 2 h. The catalyst was filtered off, and the filtrate was concentrated under vacuum to give 2-isopropyl-5-amino-pyridine (E-9) (0.55 g, 52%). 1H NMR (CDCl3) δ 8.05 (s, 1H), 6.93-6.99 (m, 2H), 3.47 (br s, 2H), 2.92-3.02 (m, 1H), 1.24-1.26 (m, 6H). ESI-MS 137.2 m/z (MH+).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-5dacbdad64c44dfdac20c45132ee683a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

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