Glycerol → n-Hexanal Glycerol

HRID 74131

반응식

HRID 74131 반응식
[CH:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH:8][CH2:9][CH:10]([CH2:12][OH:13])[OH:11]>[Pd]>[CH:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH:8][CH2:9][CH:10]([CH2:12][OH:13])[OH:11]

참가 물질

4

반응물 2

HCID 753GlycerolHCID 6184Hexanal

생성물 1

HCID 86639484n-Hexanal Glycerol

시약·촉매·용매 1

HCID 23938Palladium촉매

반응 조건

온도
200 °C

실험 절차

n-Hexanal (10.0 g, 12.3 ml, 0.1 mol), glycerol (92.09 g, 73.7 ml, 1 mol), and 10% Pd/C (5 wt %, 0.50 g) are charged to a Parr reactor, purged with nitrogen three times, heated to 200° C. with stirring and run at 1000 psi of hydrogen for 8 hrs. The reaction mixture forms two phases upon cooling. GC analysis of each phase shows complete consumption of n-hexanal. Bottom phase (glycerol): glycerol monoethers 3-hexoxy-1,2-propanediol and 2-hexoxy-1,2-propanediol (70.6%, ratio 7.8), glycerol diethers 1,3-dihexoxy-2-propanol and 2,3-dihexoxy-1-propanol (12.8%), n-hexanol (3.7%). Top phase (crude product): glycerol monoethers 3-hexoxy-1,2-propanediol and 2-hexoxy-1,2-propanediol (57.2%, ratio 8.4), glycerol diethers 1,3-dihexoxy-2-propanol and 2,3-dihexoxy-1-propanol (18.5%), n-hexanol (3.1%).

후처리

  1. custompurged with nitrogen three times
  2. temperatureThe reaction mixture forms two phases upon cooling
  3. customconsumption of n-hexanal

출처 및 근거

ORD 기록
ord-96f85a92bb594c23b10f36864333d3ba
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829229B2

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