Indoline → HCID 178418799, 화합물

HRID 7414

반응식

HRID 7414 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.CS[C:12]1[N:17]=[C:16]([OH:18])[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=1>C(O)C>[OH:18][C:16]1[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=[C:12]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][CH2:2]2)[N:17]=1

참가 물질

4

반응물 2

HCID 10328IndolineHCID 178418871HCID 178418871, 화합물

생성물 1

HCID 178418799HCID 178418799, 화합물수율 77.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of indoline (3.58 g, 30 mmol) in ethanol (50 mL) was added ethyl 2-methylthio-4-hydroxypyrimidine-5-carboxylate (5.35 g, 25 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and the precipitated crystals were collected by filtration. The crystals were washed several times with cold ethanol and dried to give the title compound (5.5 g, 77%) as crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 h
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed several times with cold ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-b3ebf651e99d40be9d11ee0c8e9016bb
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087597B1

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