Hydrochloric Acid → (2,3-Dihydro-1-benzofuran-5-yl)methanol

HRID 7422

반응식

HRID 7422 반응식
[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[C:7]([C:10](O)=[O:11])[CH:8]=[CH:9][C:2]1=2.[H-].[Al+3].[Li+].[H-].[H-].[H-].CO.Cl>O1CCCC1>[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[C:7]([CH2:10][OH:11])[CH:8]=[CH:9][C:2]1=2

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6765832,3-Dihydrobenzo(b)furan-5-carboxylic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 2776158(2,3-Dihydro-1-benzofuran-5-yl)methanol수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2,3-dihydrobenzo[b]furan-5-carboxylic acid (1.64 g, 10 mmol) in tetrahydrofuran (10 mL) was added under ice-cooling lithium aluminum hydride (949 mg, 25 mmol) and the mixture was stirred at 60° C. for 1 h. The reaction mixture was stirred under ice-cooling and methanol and 1N hydrochloric acid were added. The precipitate was filtered off and the mother liquor was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.5 g, 100%).

후처리

  1. stirringThe reaction mixture was stirred under ice-
  2. temperaturecooling
  3. filtrationThe precipitate was filtered off
  4. washthe mother liquor was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2d6bc2f5413f417781b69375e7336008
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087597B1

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