Triethylamine → 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one

HRID 742228

반응식

HRID 742228 반응식
[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([N:8]=[C:9]=[S:10])[CH:5]=[CH:6][CH:7]=1.Cl.C([O:15][C:16](=O)[CH2:17][NH:18][CH3:19])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([N:8]2[C:16](=[O:15])[CH2:17][N:18]([CH3:19])[C:9]2=[S:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1405041-Chloro-3-isothiocyanato-2-methylbenzeneHCID 171173Ethyl N-methylaminoacetate hydrochloride

생성물 1

HCID 189682123-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one수율 83.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The title compound was prepared by the procedure described in Example 1 using 13.2 g of 3-chloro-2-methylphenyl-isothiocyanate, 11.0 g of sarcosine ethyl ester hydrochloride, 25 g of triethyl amine, and 300 mL of chloroform. Crystallization from diethyl ether afforded the title compound (15.2 g) as a tan solid, m.p. 122°-124° C. Anal. Calcd. for C11H11Cl N2O S: C, 51.87; H, 4.35; N,11.00. Found: C, 51.96; H, 4.21; N, 11.05. Mass spectrum (EI, M.+) m/z 254/256.

후처리

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether

출처 및 근거

ORD 기록
ord-e1176e7dc4fa4fa3bf374c0dee41fffa
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05554607

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