3-Isopropoxybenzaldehyde → (3-Isopropoxyphenyl)methanol

HRID 742458

반응식

HRID 742458 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+]>C(O)C>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7129143-IsopropoxybenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 2759474(3-Isopropoxyphenyl)methanol수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To m-isopropoxybenzaldehyde (38 g, 0.23 mol) in 500 mL of ethanol was added slowly sodium borohydride (12.2 g, 0.32 mol) over a period of 1 h and the mixture was stirred for 2 h, filtered, and concentrated to 100 mL of its volume. The above mixture was diluted with 50 mL of water, neutralized with sulfuric acid solution with cooling, and was extracted with ether (4×100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to afford 36.32 g (95%) of m-isopropoxybenzyl alcohol.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated to 100 mL of its volume
  3. additionThe above mixture was diluted with 50 mL of water
  4. temperaturewith cooling
  5. extractionwas extracted with ether (4×100 mL)
  6. dry with materialThe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7f43f692ea4849dd80d644de78b6860a
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05554620

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