3-Fluoro-p-anisaldehyde → 3-Fluoro-4-methoxybenzyl alcohol

HRID 7427

반응식

HRID 7427 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:5][OH:6]

참가 물질

4

반응물 2

HCID 676963-Fluoro-p-anisaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 27745503-Fluoro-4-methoxybenzyl alcohol수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) in methanol (15 mL) was added under ice-cooling sodium borohydride (378 mg, 10 mmol) and the mixture was stirred at room temperature for 1 h. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1 g, 100%).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe obtained residue was dissolved in ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-731e44cf7bd248f291c99babee57228d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087597B1

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