홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Water → HCID 11516226, 화합물

HRID 743075
노트
인쇄 미리보기

반응식

HRID 743075 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]=[C:15]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][C:27]=2[NH:28]C(=O)C(Cl)(Cl)Cl)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O>C(O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH:15]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][C:27]=2[NH2:28])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]=[C:15]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][C:27]=2[NH2:28])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 19423566HCID 19423566, 화합물

생성물 2

HCID 11516226HCID 11516226, 화합물HCID 11516277HCID 11516277, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 18.0 g (34.9 mmol) of 3-[α-{(1-benzylpiperidin-4-yl)imino}benzyl]-4-trichloroacetylaminopyridine in 150 mL of ethanol was added 2.65 g (70 mmol) of sodium borohydride under ice-cooling and the mixture was stirred for 5 hours at ambient temperature. The reaction mixture was poured into water, and the ethanol was evaporated in vacuo. The residue was extracted with ethyl acetate. The organic layer separated was washed with water and then with brine, dried on anhydrous sodium sulfate and then concentrated in vacuo. Purification by means of column chromatography (silica gel, 1:9 methanol:chloroform) gave 4.82 g (12.9 mmol) of the title compound and 6.65 g (17.9 mmol) of 3-[α-{(1-benzyl-piperidin-4-yl)imino}benzyl]-4-aminopyridine.

후처리

  1. temperaturecooling
  2. customthe ethanol was evaporated in vacuo
  3. extractionThe residue was extracted with ethyl acetate
  4. customThe organic layer separated
  5. washwas washed with water
  6. dry with materialwith brine, dried on anhydrous sodium sulfate
  7. concentrationconcentrated in vacuo
  8. customPurification by means of column chromatography (silica gel, 1:9 methanol:chloroform)

출처 및 근거

ORD 기록
ord-0b0bd4d1bbf34a429811ba0d7e473c53
출처 데이터셋
uspto-grants-1996_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05556860

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트